Can I take Allopurinol and Mirtazapine together?

Why this happens

Allopurinol and mirtazapine are processed by different pathways in the body. Allopurinol works by blocking an enzyme called xanthine oxidase to lower uric acid levels, while mirtazapine affects chemical messengers in the brain. They do not interfere with each other's absorption, metabolism, or excretion.

You can take both medications as prescribed by your doctor. However, as with any combination of medicines, you should monitor for any new or unusual side effects and inform your healthcare provider if you feel unwell.

Severe skin reactions (SCARs)

Stop taking allopurinol immediately and seek urgent medical help if you develop a skin rash, peeling skin, or mouth ulcers. This can be a sign of a rare but life-threatening allergic reaction.

Agranulocytosis (low white blood cells)

Contact your doctor immediately if you develop signs of infection, such as a high temperature, sore throat, or mouth ulcers. Mirtazapine can rarely cause a serious drop in white blood cells.

Alcohol

Alcohol can increase the sedative effects of mirtazapine, making you feel much sleepier and less alert. It is best to avoid drinking alcohol while taking this medicine, especially when you first start treatment or if your dose is increased.

Water/Hydration

It is important to drink plenty of fluids (at least 2 to 3 litres a day) while taking allopurinol. This helps to prevent the formation of kidney stones and ensures the medicine works correctly.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.