Can I take Allopurinol and Nortriptyline together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known direct interaction between allopurinol and nortriptyline. However, both medications can occasionally cause side effects that affect the liver or blood counts. Taking them together does not typically increase these risks, but it is important to be aware of how you feel.
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Why this happens
Allopurinol works by lowering uric acid levels in the blood, while nortriptyline is a tricyclic antidepressant that affects brain chemicals. They are processed by different pathways in the liver and do not interfere with each other's absorption or excretion.
What you should do
Back to contentsYou can safely take these two medicines together. As with any new medication, if you notice unusual skin rashes, yellowing of the eyes or skin, or persistent sore throats, you should contact your doctor. Always ensure your doctor knows all the medicines you are taking.
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Important precautions
Back to contentsSevere skin reactions (SCARs)
Stop taking allopurinol immediately and seek urgent medical help if you develop a skin rash, peeling skin, or mouth ulcers. This can be a sign of a rare but life-threatening allergic reaction.
Heart conditions
Do not take nortriptyline if you have recently had a heart attack or have certain heart rhythm problems (such as heart block), as it can affect the electrical signals in your heart.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking nortriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid or strictly limit alcohol, especially when starting treatment or increasing your dose.
Water/Fluids
It is important to drink plenty of fluids (at least 2 litres a day) while taking allopurinol to help your kidneys flush out uric acid and prevent kidney stones.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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