Can I take Alogliptin and Amlodipine together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between alogliptin and amlodipine. Both medications can be taken together safely.
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Why this happens
Alogliptin (used for type 2 diabetes) and amlodipine (used for high blood pressure) are processed by different pathways in the body. Alogliptin is primarily cleared by the kidneys, while amlodipine is broken down by the liver. They do not interfere with how each other works or how they are removed from the system.
What you should do
Back to contentsYou can continue to take both medications as prescribed by your doctor. As with any combination of medicines for blood pressure and diabetes, it is always a good idea to monitor your blood sugar and blood pressure regularly to ensure your conditions are well-managed.
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Important precautions
Back to contentsPancreatitis
Stop taking alogliptin and see a doctor immediately if you experience severe and persistent stomach pain, which may reach through to your back, as this can be a sign of an inflamed pancreas
Liver problems
If you have liver disease, your dose may need to be adjusted or monitored more closely as amlodipine is broken down by the liver and can build up in your system.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice.
Alcohol
While there is no direct interaction, alcohol can lower your blood pressure (with amlodipine) or affect your blood sugar levels (with alogliptin). It is best to keep your intake within recommended limits and monitor how you feel.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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