Can I take Amitriptyline and Lactulose together?

Why this happens

Amitriptyline has 'anticholinergic' effects, which slow down the movement of the digestive system. Lactulose works by drawing water into the bowel to encourage movement. These two medications essentially work against each other regarding bowel habits.

It is safe to take these together, but be aware that the amitriptyline might be the cause of your constipation. If your constipation does not improve with lactulose, speak to your doctor or pharmacist about adjusting your dose or trying a different type of laxative.

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Heart conditions

Do not take amitriptyline if you have recently had a heart attack or have serious heart rhythm problems (such as heart block), as it can affect your heart rate and rhythm.

Galactosaemia or bowel obstruction

You must not use lactulose if you have a rare condition called galactosaemia (inability to process galactose) or if you have a complete blockage in your bowel.

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Caffeine (Coffee, Tea, Energy Drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen this effect and may also interfere with the medicine's ability to help you sleep.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.