Can I take Amitriptyline and Losartan together?

Why this happens

Both medications have the effect of lowering blood pressure. Losartan is specifically designed to do this, while amitriptyline can cause low blood pressure as a side effect (orthostatic hypotension). When used together, these effects add up.

You can take these together, but be careful when moving. Rise slowly from bed or chairs to avoid dizziness. If you feel very dizzy, sit or lie down immediately. Monitor your blood pressure regularly and tell your doctor if you feel constantly lightheaded or if you experience a racing heartbeat.

Pregnancy

You must not take losartan if you are pregnant or planning to become pregnant. It can cause serious harm or death to an unborn baby, particularly if used in the second and third trimesters.

Suicidal thoughts

Amitriptyline can occasionally cause an increase in suicidal thoughts or the urge to self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes significantly.

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Potassium-rich foods and salt substitutes

Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes (such as Lo-Salt) that contain potassium. You should also avoid consuming very large amounts of potassium-rich foods like bananas, spinach, or coconut water, unless advised otherwise by your doctor.

Grapefruit juice

Grapefruit juice may increase the amount of amitriptyline in your blood, which could increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.