Can I take Amitriptyline and Shortec together?

Why this happens

Both medicines act on the central nervous system to slow down brain activity. Amitriptyline is a tricyclic antidepressant and Shortec is an opioid painkiller; when used together, their sedative effects add up. Additionally, both drugs have 'anticholinergic' effects, which multiply the risk of side effects like constipation and blurred vision.

You should only take these two medicines together if they have been specifically prescribed by your doctor with the knowledge that you are taking both. If you feel excessively sleepy, have shallow breathing, or feel like you might faint, seek medical help immediately. Avoid driving or operating machinery until you know how this combination affects you. Do not drink alcohol while taking these medicines.

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Respiratory Depression Risk

Taking these medicines together significantly increases the risk of dangerous breathing difficulties and extreme sleepiness. Do not take other sedatives or drink alcohol while using this combination.

Opioid Dependence and Addiction

Shortec is an opioid that can cause addiction and withdrawal symptoms. It should only be used for the shortest time possible; long-term use for non-cancer pain is rarely effective and increases the risk of dependency.

Heart Rhythm Disorders

Amitriptyline can affect your heart rhythm. It must be used with caution if you have a history of heart disease or a recent heart attack, as it can increase the risk of serious arrhythmias.

Alcohol

You must avoid drinking alcohol while taking these medicines. Both amitriptyline and Shortec cause drowsiness and slow down your breathing. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and loss of consciousness.

Grapefruit juice

Avoid drinking grapefruit juice or eating grapefruit. It can increase the amount of Shortec in your bloodstream, making side effects like extreme sleepiness or breathing problems more likely.

Caffeine (Coffee, tea, energy drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen this effect and may also increase feelings of restlessness or anxiety.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.