Can I take Amlodipine and Aspirin 300 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking aspirin with amlodipine may slightly increase the risk of stomach irritation or bleeding, and high doses of aspirin (like 300mg) can sometimes make blood pressure medication slightly less effective.
In this article:
Continue reading below
Why this happens
Aspirin belongs to a group of medicines called NSAIDs. These can cause the body to hold onto salt and water, which works against amlodipine's job of lowering blood pressure. Additionally, both medicines can affect blood flow and the lining of the stomach.
What you should do
Back to contentsIt is generally safe to take these together occasionally, but you should monitor your blood pressure regularly. If you need to take 300mg of aspirin frequently, speak to your GP or pharmacist, as they may prefer you to use a different painkiller like paracetamol which does not affect blood pressure. Seek medical advice if you notice any unusual bruising or dark, tarry stools.
Continue reading below
Important precautions
Back to contentsAsthma
Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening asthma attack.
Stomach ulcers or bleeding disorders
Avoid aspirin if you have an active stomach ulcer or a history of bleeding problems, as it significantly increases the risk of serious internal bleeding.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your body and may cause your blood pressure to drop too low. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.
Alcohol
Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a sensitive stomach.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Amitriptyline and Ramipril together?
Taking amitriptyline and ramipril together can cause your blood pressure to drop lower than intended. This is most common when you first start the medication or when your dose is increased. You may feel dizzy, lightheaded, or faint, especially when standing up quickly from a sitting or lying position.
Treatment and medication
Can I take Amoxicillin and Sertraline together?
There is no known direct interaction between amoxicillin and sertraline. It is generally considered safe to take these two medications together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.