Can I take Amlodipine and Aspirin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking amlodipine and aspirin together is generally considered safe, but there is a small chance that aspirin could slightly reduce how well amlodipine works to lower your blood pressure. Additionally, both medications can independently increase the risk of stomach irritation or bruising, though this is rarely a significant problem at standard doses.
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Why this happens
Aspirin belongs to a group of medicines called NSAIDs. These can sometimes cause the body to hold onto salt and water, and they can interfere with natural chemicals called prostaglandins that help keep blood vessels relaxed. This can slightly counteract the blood-pressure-lowering effect of amlodipine.
What you should do
Back to contentsYou can usually take these two medicines together. However, you should monitor your blood pressure regularly to ensure it stays within the target range set by your doctor. If you notice your blood pressure rising or if you experience unusual bruising or stomach pain, speak to your GP or pharmacist.
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Important precautions
Back to contentsAsthma
Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening asthma attack.
Stomach ulcers or bleeding disorders
Avoid aspirin if you have an active stomach ulcer or a history of bleeding problems, as it significantly increases the risk of serious internal bleeding.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your body and may cause your blood pressure to drop too low. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.
Alcohol
Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a sensitive stomach.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking amlodipine and amitriptyline together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly from a sitting or lying position. There is also a small risk that both medications could affect your heart rhythm.
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Can I take Alcohol and Codeine together?
Combining alcohol and codeine can lead to extreme sleepiness, dizziness, and a dangerous slowing of your breathing. In severe cases, this can lead to unconsciousness, coma, or even death. It also increases the risk of accidents and falls.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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