Can I take Amlodipine and Doxadura together?

Why this happens

Both amlodipine and doxazosin (Doxadura) work by relaxing and widening your blood vessels to lower blood pressure. When used together, their effects add up (an additive effect), which can sometimes lower blood pressure too much.

It is common for doctors to prescribe these together, but you should be cautious. When starting this combination or increasing the dose, get up slowly from a bed or chair to avoid dizziness. Monitor your blood pressure regularly at home if possible. If you feel very dizzy, faint, or have a racing heartbeat, contact your doctor.

First-dose hypotension

Doxadura can cause a severe drop in blood pressure when you first start it or increase the dose. Take your first dose at bedtime and be very careful when standing up to avoid fainting or dizziness.

Grapefruit consumption

Avoid drinking large amounts of grapefruit juice or eating grapefruit. It can significantly increase the level of amlodipine in your blood, making your blood pressure drop too low.

Cataract surgery

If you are planning to have eye surgery for cataracts, you must tell your eye surgeon you are taking Doxadura. It can cause 'Floppy Iris Syndrome', which may complicate the procedure.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may lower your blood pressure too much. You should avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol can increase the blood-pressure-lowering effect of these medicines. This may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.