Can I take Amlodipine and Metformin together?

Why this happens

Amlodipine belongs to a class of drugs called calcium channel blockers. These can sometimes interfere with how the body releases insulin and how it processes sugar, which can slightly oppose the work that metformin does to lower blood sugar.

It is generally safe to take these two medicines together, as the interaction is mild. However, you should monitor your blood sugar levels more closely when you first start amlodipine or if your dose is increased. If you notice your blood sugar readings are consistently higher than your target range, speak to your doctor, as they may need to adjust your metformin dose.

Severe kidney or liver problems

You must not take metformin if you have severe kidney or liver failure, as this significantly increases the risk of lactic acidosis, a rare but life-threatening build-up of acid in the blood.

X-ray or scan using iodine contrast dye

You must stop taking metformin before and for 48 hours after having an X-ray or scan involving an injection of iodine contrast dye, as the combination can cause sudden kidney failure.

Severe liver disease

Amlodipine is broken down slowly by the liver; if you have severe liver problems, the medicine can build up to dangerous levels in your body, requiring a much lower dose or close monitoring.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice.

Alcohol

Avoid drinking excessive amounts of alcohol while taking metformin. Alcohol can increase the risk of a rare but serious condition called lactic acidosis and can also affect your blood sugar control.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.