Can I take Amlodipine and Quetiapine together?

Why this happens

Both amlodipine and quetiapine have the side effect of lowering blood pressure. Amlodipine is designed to do this, but quetiapine can also cause 'orthostatic hypotension' (a drop in blood pressure when standing). When used together, these effects add up. Additionally, quetiapine can occasionally affect the electrical activity of the heart (QT prolongation), and while amlodipine doesn't usually cause this, the combination requires caution.

You can take these medicines together, but you should be careful. To prevent dizziness, try to stand up slowly. If you feel very dizzy, faint, or notice a fast or pounding heartbeat, contact your doctor. Your doctor may want to monitor your blood pressure more closely when you first start this combination or if your dose is changed.

Dementia in elderly patients

There is an increased risk of stroke and death when quetiapine used to treat dementia-related psychosis in elderly patients.

Heart rhythm disorders (Long QT syndrome)

Quetiapine can affect your heart rhythm. You must tell your doctor if you have a history of heart rhythm problems or are taking other medicines that affect the heart.

Severe liver disease

Amlodipine is broken down very slowly by the liver; if you have liver problems, the dose must be adjusted carefully to avoid toxic build-up.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may lower your blood pressure too much. Avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Alcohol can increase the blood-pressure lowering effect of amlodipine, making you feel dizzy or lightheaded. For quetiapine, alcohol can increase drowsiness and impair your coordination. It is best to limit or avoid alcohol while taking these medicines.

High-fat meals

If you are taking the extended-release (XL) version of quetiapine, you should avoid taking it with a very heavy or high-fat meal, as this can cause the medicine to be absorbed too quickly into your system. It is usually recommended to take it without food or with a light snack.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.