Can I take Codeine and Ibuprofen together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no harmful interaction between codeine and ibuprofen. In fact, they are often taken together because they work in different ways to provide better pain relief than either medicine alone.
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Why this happens
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation at the site of injury. Codeine is an opioid that works in the brain and spinal cord to change how your body feels and responds to pain. Because they target pain through different pathways, their effects are additive.
What you should do
Back to contentsIt is safe to take these together, provided you do not exceed the recommended dose for either medication. Be aware that many "plus" or "extra" branded painkillers already contain both ingredients (such as Nurofen Plus), so always check the packaging to avoid accidentally taking a double dose. Common side effects when taking both may include constipation or an upset stomach.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Addiction and Dependency
This medicine contains an opioid which can cause addiction if used for more than 3 days. Long-term use can lead to withdrawal symptoms when you stop.
Stomach Ulcers or Bleeding
Avoid this medicine if you have ever had a stomach ulcer or gastrointestinal bleeding, as it can cause serious internal bleeding or perforation.
Food and drink warnings
Back to contentsAlcohol
You must avoid drinking alcohol while taking codeine. Both alcohol and codeine are central nervous system depressants. Combining them significantly increases the risk of severe drowsiness, dizziness, and dangerous breathing problems (respiratory depression).
Food (General)
You should ideally take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduces the chance of indigestion or stomach upset.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking Rybelsus (semaglutide) alongside amlodipine may occasionally lead to a further drop in blood pressure. While Rybelsus is primarily for blood sugar, it can sometimes cause a slight reduction in blood pressure or a small increase in heart rate. When combined with a blood pressure medicine like amlodipine, you might feel slightly more dizzy or lightheaded, especially when standing up quickly.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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