Can I take Empagliflozin and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). You may also have a higher risk of becoming dehydrated or experiencing a rare but serious condition called ketoacidosis.
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Why this happens
Both medicines work to lower blood sugar but in different ways. Empagliflozin (Jardiance) makes you pass sugar out through your urine, while Rybelsus (semaglutide) helps your body release more insulin. Because they both lower blood sugar, their combined effect is much stronger. Additionally, empagliflozin is a diuretic (water pill) effect, which can lead to fluid loss.
What you should do
Back to contentsYou should only take these together if prescribed by your doctor. Monitor your blood sugar levels regularly. Learn to recognise signs of 'hypos' (such as shaking, sweating, or confusion) and keep a fast-acting sugar source nearby. Ensure you drink plenty of water to stay hydrated. If you feel very unwell, nauseated, or have stomach pain, contact your doctor immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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