Can I take Fexofenadine and Trazodone together?

Why this happens

Both medications can affect the central nervous system. Trazodone is a sedative antidepressant, and fexofenadine, although designed not to enter the brain easily, can occasionally cause mild drowsiness. When used together, these effects can combine (additive effect).

It is generally safe to take these together, but you should be aware of how they affect you. Avoid driving or operating heavy machinery until you know how this combination makes you feel. If you experience extreme sleepiness or feel very unsteady on your feet, speak to your doctor or pharmacist.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.