Can I take Oestrogel pump-pack /actuation and Vitamin c together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking high doses of Vitamin C (ascorbic acid) alongside Oestrogel can increase the levels of oestrogen in your bloodstream. This might increase the risk of oestrogen-related side effects, such as breast tenderness, bloating, or nausea. Conversely, if you suddenly stop taking Vitamin C after your body has adjusted to the combination, your oestrogen levels could drop, potentially causing a return of menopause symptoms.
In this article:
Continue reading below
Why this happens
Both Vitamin C and oestrogen (estradiol) compete for the same 'breakdown' process in the body (specifically a process called sulfation). Because the Vitamin C keeps the breakdown enzymes busy, less oestrogen is cleared from your system, leading to higher levels in the blood.
What you should do
Back to contentsYou do not need to avoid Vitamin C, but you should avoid taking very high doses (over 1,000mg per day) of Vitamin C supplements. If you are already taking a Vitamin C supplement, try to be consistent with your daily dose rather than starting and stopping it abruptly. If you notice increased breast pain or other side effects, speak to your doctor.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Amitriptyline and Sertraline together?
Taking amitriptyline and sertraline together can lead to a serious condition called serotonin syndrome. It can also cause amitriptyline levels to build up in your body, increasing the risk of side effects like extreme sleepiness, a dry mouth, blurred vision, or an irregular heartbeat.

Treatment and medication
Can I take Amitriptyline and Tizanidine together?
Taking amitriptyline and tizanidine together can make you feel extremely drowsy, dizzy, and lightheaded. It can also cause a significant drop in blood pressure, which might lead to fainting. You may find it very difficult to concentrate or perform tasks that require alertness.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.