Can I take Adcal-D3 and Omega-3 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no known harmful interaction between Adcal-D3 and Omega-3 (fish oil) supplements. In fact, taking them together may be slightly beneficial for bone health.
In this article:
Continue reading below
Why this happens
Adcal-D3 contains calcium and vitamin D3. Omega-3 fatty acids do not interfere with how the body absorbs or processes calcium or vitamin D. Some studies suggest that vitamin D is absorbed better when taken with a meal containing fats (like omega-3), and both substances work together to support bone density.
What you should do
Back to contentsIt is safe to take these two supplements together. For the best absorption of both, take them with your largest meal of the day. Always inform your doctor or pharmacist about all the supplements you are taking.
Continue reading below
Important precautions
Back to contentsKidney stones or severe kidney disease
Do not take Adcal-D3 if you have a history of kidney stones or severe kidney impairment, as it can increase the risk of further stone formation and cause calcium to build up to dangerous levels in your blood.
High blood calcium (Hypercalcaemia)
You must not take Adcal-D3 if you have been told you have high levels of calcium in your blood or urine (often caused by overactive parathyroid glands or certain bone cancers), as it can lead to heart rhythm problems or kidney damage.
Bleeding disorders or use of blood thinners (e.g., Warfarin)
High doses of omega-3 can increase your risk of bleeding. If you take blood-thinning medication or have a bleeding disorder, you must be monitored closely as your dose may need adjustment.
Food and drink warnings
Back to contentsCaffeine (Tea, Coffee, Cola)
Caffeine can reduce the amount of calcium your body absorbs. It is best to limit high caffeine intake or avoid having these drinks at the same time as your supplement.
Foods high in Fibre or Oxalic Acid or Phytic Acid (Spinach, Rhubarb, Whole-grain cereals)
These foods can bind to calcium and prevent it from being absorbed properly. You should wait at least 2 hours after eating these foods before taking your Adcal.
High-fat meals
Taking omega-3 supplements with a meal containing some fat significantly improves how well the oil is absorbed by your body.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Amlodipine and Metformin together?
Amlodipine may slightly reduce the blood sugar-lowering effects of metformin. This means your blood sugar levels might be a little higher than usual when taking both medicines together.

Treatment and medication
Can I take Amlodipine and Atorvastatin together?
Taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a more serious muscle breakdown called rhabdomyolysis.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.