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Can I take Adcal-D3 and Omega-3 together?

Drug interaction guide

There is no known harmful interaction between Adcal-D3 and Omega-3 (fish oil) supplements. In fact, taking them together may be slightly beneficial for bone health.

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Why this happens

Adcal-D3 contains calcium and vitamin D3. Omega-3 fatty acids do not interfere with how the body absorbs or processes calcium or vitamin D. Some studies suggest that vitamin D is absorbed better when taken with a meal containing fats (like omega-3), and both substances work together to support bone density.

It is safe to take these two supplements together. For the best absorption of both, take them with your largest meal of the day. Always inform your doctor or pharmacist about all the supplements you are taking.

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Kidney stones or severe kidney disease

Do not take Adcal-D3 if you have a history of kidney stones or severe kidney impairment, as it can increase the risk of further stone formation and cause calcium to build up to dangerous levels in your blood.

High blood calcium (Hypercalcaemia)

You must not take Adcal-D3 if you have been told you have high levels of calcium in your blood or urine (often caused by overactive parathyroid glands or certain bone cancers), as it can lead to heart rhythm problems or kidney damage.

Bleeding disorders or use of blood thinners (e.g., Warfarin)

High doses of omega-3 can increase your risk of bleeding. If you take blood-thinning medication or have a bleeding disorder, you must be monitored closely as your dose may need adjustment.

Caffeine (Tea, Coffee, Cola)

Caffeine can reduce the amount of calcium your body absorbs. It is best to limit high caffeine intake or avoid having these drinks at the same time as your supplement.

Foods high in Fibre or Oxalic Acid or Phytic Acid (Spinach, Rhubarb, Whole-grain cereals)

These foods can bind to calcium and prevent it from being absorbed properly. You should wait at least 2 hours after eating these foods before taking your Adcal.

High-fat meals

Taking omega-3 supplements with a meal containing some fat significantly improves how well the oil is absorbed by your body.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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