Can I take Black cohosh and Solifenacin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking black cohosh and solifenacin together may increase the risk of side effects such as a dry mouth, blurred vision, constipation, or feeling overheated. There is also a small possibility that black cohosh could affect how your liver breaks down solifenacin, potentially leading to higher levels of the medicine in your body.
In this article:
Continue reading below
Why this happens
Both substances can have 'anticholinergic' effects (blocking a specific chemical messenger in the body), which can lead to additive side effects. Additionally, some studies suggest black cohosh may interfere with liver enzymes (specifically CYP3A4) that are responsible for clearing solifenacin from your system.
What you should do
Back to contentsUse this combination with caution. If you decide to take both, monitor yourself closely for increased side effects like severe constipation, difficulty urinating, or extreme dry mouth. It is best to inform your doctor or pharmacist before starting black cohosh if you are already prescribed solifenacin for overactive bladder.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Amlodipine and Aspirin together?
Taking amlodipine and aspirin together is generally considered safe, but there is a small chance that aspirin could slightly reduce how well amlodipine works to lower your blood pressure. Additionally, both medications can independently increase the risk of stomach irritation or bruising, though this is rarely a significant problem at standard doses.
Treatment and medication
Can I take Amlodipine and Rybelsus together?
Taking Rybelsus (semaglutide) alongside amlodipine may occasionally lead to a further drop in blood pressure. While Rybelsus is primarily for blood sugar, it can sometimes cause a slight reduction in blood pressure or a small increase in heart rate. When combined with a blood pressure medicine like amlodipine, you might feel slightly more dizzy or lightheaded, especially when standing up quickly.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.