Can I take Fexofenadine and Losartan together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between fexofenadine and losartan. It is generally considered safe to take these two medications together.
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Why this happens
Fexofenadine is an antihistamine that is mostly removed from the body unchanged by the kidneys and liver. Losartan is a blood pressure medication processed by specific liver enzymes (CYP2C9 and CYP3A4). Because they use different pathways in the body and do not affect each other's absorption or action, they do not interfere with one another.
What you should do
Back to contentsYou can take both medications as prescribed by your doctor. However, always monitor your blood pressure regularly and be aware that some hay fever symptoms can occasionally feel like the side effects of blood pressure medicine (such as dizziness). If you feel unwell, consult your pharmacist or GP.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking Rybelsus (semaglutide) alongside amlodipine may occasionally lead to a further drop in blood pressure. While Rybelsus is primarily for blood sugar, it can sometimes cause a slight reduction in blood pressure or a small increase in heart rate. When combined with a blood pressure medicine like amlodipine, you might feel slightly more dizzy or lightheaded, especially when standing up quickly.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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