Can I take Flecainide and Mirabegron astellas together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking these two medicines together can increase the level of flecainide in your blood. This may increase the risk of side effects, such as an irregular heartbeat (arrhythmia), dizziness, or blurred vision.
In this article:
Continue reading below
Why this happens
Mirabegron can slow down the action of a specific enzyme in the liver (called CYP2D6) that is responsible for breaking down flecainide. Because the flecainide is broken down more slowly, it can build up to higher levels in your body.
What you should do
Back to contentsYou should speak to your doctor before taking these medicines together. Your doctor may need to adjust your dose of flecainide or monitor your heart rhythm more closely using an ECG (electrocardiogram). If you experience any new palpitations, fainting, or shortness of breath, seek medical advice immediately.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Amlodipine and Aspirin together?
Taking amlodipine and aspirin together is generally considered safe, but there is a small chance that aspirin could slightly reduce how well amlodipine works to lower your blood pressure. Additionally, both medications can independently increase the risk of stomach irritation or bruising, though this is rarely a significant problem at standard doses.

Treatment and medication
Can I take Amlodipine and Nustendi together?
Taking amlodipine and Nustendi (ezetimibe) together can increase the amount of one of the ingredients in Nustendi (bempedoic acid) in your bloodstream. This may increase the risk of side effects from Nustendi, such as high levels of uric acid in the blood (which can cause gout) or, in rare cases, tendon problems.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.