Can I take Omeprazole and Simvastatin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking omeprazole and simvastatin together can increase the amount of simvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, weakness, or a rare but serious condition called rhabdomyolysis (muscle breakdown).
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Why this happens
Both drugs are processed by the same enzymes in the liver. Omeprazole can slow down the breakdown of simvastatin, leading to higher levels of the statin remaining in your body.
What you should do
Back to contentsYou can take these together, but you should be aware of the increased risk. If you experience any unexplained muscle pain, tenderness, or weakness, contact your doctor immediately. Your doctor may choose to limit your simvastatin dose to 20mg or 40mg daily, or monitor you more closely.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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