Can I take Prozac and Wellbutrin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking Prozac (fluoxetine) and Wellbutrin (bupropion) together can significantly increase the levels of Prozac in your blood. This can lead to an increased risk of side effects such as anxiety, sleep problems, tremors, or jitteriness. More seriously, both medications can lower the 'seizure threshold', meaning there is a higher risk of having a seizure when they are combined. There is also a small risk of 'serotonin syndrome', a rare but serious condition caused by too much serotonin in the brain.
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Why this happens
Wellbutrin (bupropion) blocks a specific liver enzyme (CYP2D6) that the body uses to break down Prozac (fluoxetine). Because the Prozac isn't being cleared out as quickly, it builds up to higher levels. Additionally, both drugs affect brain chemicals in a way that can make the brain more prone to seizures.
What you should do
Back to contentsYou must speak to your doctor before taking these together. If your doctor decides this combination is necessary, they may prescribe a lower dose of one or both medications. Seek immediate medical help if you experience a seizure, extreme confusion, severe muscle stiffness, or a very high fever.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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