Can I take Sildenafil and Atorvastatin together?

Why this happens

These medicines work in different ways and are processed by different pathways in the body. Atorvastatin works on the liver to lower cholesterol, while sildenafil works on blood vessels to improve blood flow. They do not interfere with each other's absorption or effectiveness.

You can continue to take both medicines as prescribed by your doctor. However, if you have a history of heart disease or high blood pressure (which are common reasons for taking atorvastatin), ensure your doctor has confirmed that you are healthy enough for sexual activity before using sildenafil. Always inform your healthcare provider of all medicines you are taking.

Nitrate medication use (e.g. GTN spray, isosorbide mononitrate)

You must never take sildenafil if you use nitrate medicines for chest pain or heart failure. Taking them together can cause a sudden, life-threatening drop in blood pressure.

Pregnancy

Do not take atorvastatin if you are pregnant or planning to become pregnant. It can cause serious harm to an unborn baby. Use reliable contraception while taking this medicine.

Unexplained muscle pain or weakness - atorvastatin

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney damage.

Grapefruit juice

Grapefruit juice can increase the levels of these medicines in your blood, which may increase the risk of side effects. For atorvastatin, avoid drinking large amounts (more than 1.2 litres daily). For sildenafil, it is best to avoid grapefruit juice altogether as it can increase the risk of headaches, flushing, or low blood pressure.

High-fat meals

Eating a heavy or high-fat meal (such as a burger or chips) just before taking sildenafil can delay how quickly the medicine starts to work. For the fastest effect, take it on an empty stomach or with a light meal.

Alcohol

While there is no direct interaction, drinking large amounts of alcohol with atorvastatin can increase your risk of liver problems. With sildenafil, alcohol can make it harder to get an erection and may increase the risk of dizziness or low blood pressure. It is best to keep alcohol intake to a minimum.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.