Can I take Amlodipine and Lansoprazole together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known significant interaction between amlodipine and lansoprazole. These two medicines are commonly prescribed together and are generally considered safe to take at the same time.
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Why this happens
Amlodipine (a blood pressure medicine) and lansoprazole (a stomach acid reducer) are processed by different pathways in the body and do not interfere with how the other works.
What you should do
Back to contentsYou can continue to take both medicines as prescribed by your doctor. You do not need to change the timing of your doses or take any special precautions regarding this specific combination.
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Important precautions
Back to contentsLiver disease
Amlodipine is broken down by the liver; if your liver is not working fully, the medicine can build up to toxic levels. Your doctor must monitor you closely and may need to use a much lower starting dose.
Severe diarrhoea
Lansoprazole can increase the risk of serious bacterial bowel infections (such as Campylobacter or C. difficile). If you develop severe or persistent watery diarrhoea, seek medical advice immediately and do not use anti-diarrhoeal medicines.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swelling. Avoid drinking large amounts of grapefruit juice.
Alcohol
While alcohol does not directly interact with amlodipine, both can lower your blood pressure. Drinking alcohol while taking this medicine may make you feel dizzy, lightheaded, or sleepy. It is best to keep alcohol intake to a minimum.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Amlodipine and Doxadura together?
Taking these two medicines together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when you stand up quickly from a sitting or lying position.
Treatment and medication
Can I take Amlodipine and Aspirin 300 together?
Taking aspirin with amlodipine may slightly increase the risk of stomach irritation or bleeding, and high doses of aspirin (like 300mg) can sometimes make blood pressure medication slightly less effective.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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